Placental protein 13, galectin 14 and pentraxin 3 for prediction of preeclampsia in Egyptian patients
Ali, Fahmy; Hassan, Nahla; Soliman, Reham; Ibrahim, Ahmed;
Abstract
Background: Pre-eclampsia (PE) is considered one of the most dangerous pregnancy complications, and the leading cause
of maternal and perinatal mortality and morbidity. Objective: The aim of the current study was to evaluate two galectins
(GAL) and some biochemical parameters in the diagnosis of PE. Materials and Methods: The study included a total of
96 women, including 66 pregnant women with PE, and 30 normotensive pregnant females. The biomarkers studied, at the
3 trimesters, included GAL13 and 14, pentraxin 3 (PTX3), C-reactive protein (CRP), liver function tests, and lipid profile.
Results: Results indicated that a significant difference in GAL13 and 14 and PTX3 in preeclamptic women compared to
normotensive pregnant ones. The level of CRP showed non-significant change in all patient’s groups. Liver function tests,
total cholesterol, low-density lipoprotein cholesterol, and triacylglycerols revealed a high significant increase in all patient’s
groups. Levels of high-density lipoprotein cholesterol were highly significant decreased in 2nd and 3rd-trimester patients.
Conclusion: The specificity and sensitivity of GAL14 provided the highest diagnostic information of these biomarkers and
are in close to GAL13 and PTX3; while, CRP yielded a significantly worse accuracy for diagnosing PE.
of maternal and perinatal mortality and morbidity. Objective: The aim of the current study was to evaluate two galectins
(GAL) and some biochemical parameters in the diagnosis of PE. Materials and Methods: The study included a total of
96 women, including 66 pregnant women with PE, and 30 normotensive pregnant females. The biomarkers studied, at the
3 trimesters, included GAL13 and 14, pentraxin 3 (PTX3), C-reactive protein (CRP), liver function tests, and lipid profile.
Results: Results indicated that a significant difference in GAL13 and 14 and PTX3 in preeclamptic women compared to
normotensive pregnant ones. The level of CRP showed non-significant change in all patient’s groups. Liver function tests,
total cholesterol, low-density lipoprotein cholesterol, and triacylglycerols revealed a high significant increase in all patient’s
groups. Levels of high-density lipoprotein cholesterol were highly significant decreased in 2nd and 3rd-trimester patients.
Conclusion: The specificity and sensitivity of GAL14 provided the highest diagnostic information of these biomarkers and
are in close to GAL13 and PTX3; while, CRP yielded a significantly worse accuracy for diagnosing PE.
Other data
Title | Placental protein 13, galectin 14 and pentraxin 3 for prediction of preeclampsia in Egyptian patients | Authors | Ali, Fahmy ; Hassan, Nahla ; Soliman, Reham ; Ibrahim, Ahmed | Keywords | Preeclampsia; Galectins 13; Galectins 14; Pentraxin 3 | Issue Date | 2018 | Journal | International Journal of Medical Science and Public Health | DOI | 1 10.5455/ijmsph.2018.0206709032018 |
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