The Synonymous Isocitrate Dehydrogenase 1 315C>T SNP Confers an Adverse Prognosis in Egyptian Adult Patients with NPM1-/CEBPA-Negative Acute Myeloid Leukemia
Ali, M.A.M.; Ahmed, Emad; Assem, M.M.A.; Helwa, R.;
Abstract
© 2017, Indian Society of Haematology & Transfusion Medicine. Although the clinical features of isocitrate dehydrogenase (IDH) genetic aberrations have been well-characterized in acute myeloid leukemia (AML), definitive information on their prognostic significance is lacking. We aimed to explore the prognostic significance of IDH gene alterations in an Egyptian cohort of adult patients with de novo AML. Diagnostic peripheral blood samples from 51 AML patients were analyzed for the presence of mutations/SNPs in exon 4 of IDH1 and IDH2 genes using polymerase chain reaction amplification followed by direct sequencing. IDH mutational status had no impact on event-free survival (EFS) and overall survival (OS), whereas the presence of IDH1 315C>T SNP was significantly associated with inferior EFS (P = 0.037) and OS (P = 0.034) as compared with wild-type IDH1. IDH1 315C>T SNP but not IDH mutations is associated with unfavorable outcomes, suggesting that AML patients with IDH1 315C>T SNP can represent a new subgroup of patients which allows refined risk stratification.
Other data
Title | The Synonymous Isocitrate Dehydrogenase 1 315C>T SNP Confers an Adverse Prognosis in Egyptian Adult Patients with NPM1-/CEBPA-Negative Acute Myeloid Leukemia | Authors | Ali, M.A.M. ; Ahmed, Emad ; Assem, M.M.A. ; Helwa, R. | Issue Date | 2017 | Journal | Indian Journal of Hematology and Blood Transfusion | DOI | 2 240 http://www.scopus.com/inward/record.url?eid=2-s2.0-85025592483&partnerID=MN8TOARS 34 10.1007/s12288-017-0852-6 |
PubMed ID | 29622865 | Scopus ID | 2-s2.0-85025592483 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.