Tubulin and Tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases
Mohamed Salama; Ali Shalash; Alshimaa Magdy; Marianne Makar; roushdy, tamer; Mahmoud Elbalkimy; Hanan Elrassas; Passent Elkafrawy; Wael Mohamed; Mohamed B. Abou Donia; Firas H. Kobeissy;
Abstract
© 2018 Salama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by progressive neuronal loss and pathological accumulation of some proteins. Developing new biomarkers for both diseases is highly important for the early diagnosis and possible development of neuro-protective strategies. Serum antibodies (AIAs) against neuronal proteins are potential biomarkers for AD and PD that may be formed in response to their release into systemic circulation after brain damage. In the present study, two AIAs (tubulin and tau) were measured in sera of patients of PD and AD, compared to healthy controls. Results showed that both antibodies were elevated in patients with PD and AD compared to match controls. Curiously, the profile of elevation of antibodies was different in both diseases. In PD cases, tubulin and tau AIAs levels were similar. On the other hand, AD patients showed more elevation of tau AIAs compared to tubulin. Our current results suggested that AIAs panel could be able to identify cases with neuro-degeneration when compared with healthy subjects. More interestingly, it is possible to differentiate between PD and AD cases through identifying specific AIAs profile for each neurodegenerative states.
Other data
Title | Tubulin and Tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases | Authors | Mohamed Salama ; Ali Shalash ; Alshimaa Magdy ; Marianne Makar ; roushdy, tamer ; Mahmoud Elbalkimy ; Hanan Elrassas ; Passent Elkafrawy ; Wael Mohamed ; Mohamed B. Abou Donia ; Firas H. Kobeissy | Issue Date | 9-May-2018 | Source | Salama M, Shalash A, Magdy A, Makar M, Roushdy T, Elbalkimy M, et al. (2018) Tubulin and Tau: Possible targets for diagnosis of Parkinson's and Alzheimer's diseases. PLoS ONE 13(5): e0196436. https://doi.org/10.1371/journal. pone.0196436 | Journal | {PLOS} {ONE} | DOI | 5 e0196436 https://api.elsevier.com/content/abstract/scopus_id/85046777377 13 1932-6203 10.1371/journal.pone.0196436 |
PubMed ID | 13 | Scopus ID | 2-s2.0-85046777377 |
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