Preparation of Chitosan Antioxidant Nanoparticles as Drug Delivery System for Enhancing of Anti-Cancer Drug
Hassan M. Ibrahim; Omar A. Farid; Samir, Amany; Rehab M. Mosaad;
Abstract
Chemotherapy is a major therapeutic approach for the treatment of localized and
metastasized cancers. Although Doxorubicin (DOX) possesses abroad spectrum of anticancer
activity, its clinical use is limited because of it cause heart failure. Chitosan nanoparticles was
prepared by using ionic gelation method. These nanoaparticles were used as polyload of anticancer
DOX to form safer and non-toxic anticancer drug. infrared spectroscopy (FTIR) and transmission
electron microscope (TEM) were used to characterize the prepared nanoparticles. The cancer
animals’ experiments using Ehrlich static cancer, (EAC) cells using six groups of experimental
animals were performed to evaluate the efficiency of Doxorubicin and Doxorubicin loaded chitosan
nanoparticles as anticancer drug especially from its toxicity towards heart. Tumor volume was
calculated as to monitor the response to treatment. Cytotoxicity of Doxorubicin and Doxorubicin
loaded chitosan nanoparticles were evaluated. Biochemical parameters were be estimated to illustrate
the cytotoxicity of these drugs on heart.
metastasized cancers. Although Doxorubicin (DOX) possesses abroad spectrum of anticancer
activity, its clinical use is limited because of it cause heart failure. Chitosan nanoparticles was
prepared by using ionic gelation method. These nanoaparticles were used as polyload of anticancer
DOX to form safer and non-toxic anticancer drug. infrared spectroscopy (FTIR) and transmission
electron microscope (TEM) were used to characterize the prepared nanoparticles. The cancer
animals’ experiments using Ehrlich static cancer, (EAC) cells using six groups of experimental
animals were performed to evaluate the efficiency of Doxorubicin and Doxorubicin loaded chitosan
nanoparticles as anticancer drug especially from its toxicity towards heart. Tumor volume was
calculated as to monitor the response to treatment. Cytotoxicity of Doxorubicin and Doxorubicin
loaded chitosan nanoparticles were evaluated. Biochemical parameters were be estimated to illustrate
the cytotoxicity of these drugs on heart.
Other data
Title | Preparation of Chitosan Antioxidant Nanoparticles as Drug Delivery System for Enhancing of Anti-Cancer Drug | Authors | Hassan M. Ibrahim ; Omar A. Farid ; Samir, Amany ; Rehab M. Mosaad | Keywords | Doxorubicin; anticancer drugs; chitosan nanoparticles; poly load; drug delivery; anti-oxidant. | Issue Date | 5-Jan-2018 | Publisher | Key Engineering Materials | DOI | 10.4028/www.scientific.net/KEM.759.92 |
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