Biological study of the effect of water soluble [N-(2-hydroxybenzyl)-l-aspartato] gallium complexes on breast carcinoma and fibrosarcoma cells
Mohsen, A.; Collery, P.; Hassan, R.E.; Badawi, A.; Jeannesson, P.; Desmaële, D.; Morjani, H.; Gilane Mohamed Sabry;
Abstract
© 2016, SBIC. Abstract: Two water soluble gallium complexes described as [Ga(III)LCl], where l is the deprotonated form of N-2-hydroxybenzyl aspartic acid derivatives, were synthesized and characterized by1H NMR,13C NMR, FT-IR, mass spectrometry, and elemental analysis. The 2-(5-chloro-2-hydroxybenzylamino)succinic acid derivative (GS2) has been found to be a promising anticancer drug candidate. This compound was found to be more cytotoxic against human breast carcinoma MDA-MB231 and fibrosarcoma HT-1080 cell lines than the unsubstituted derivative and GaCl3. GS2 was able to induce apoptosis through downregulation of AKT phosphorylation, G2M arrest in cell cycle, and caspase 3/7 pathway. This gallium complex was found to induce an increase in mitochondrial ROS level in HT-1080 cells but not in MDA-MB231 cells. This suggests that the mechanism of action of GS2 would not be mediated by the drug-induced oxidative stress but probably by directly and indirectly inhibiting the AKT cell-signaling pathway. Graphical abstract: [Figure not available: see fulltext.]
Other data
Title | Biological study of the effect of water soluble [N-(2-hydroxybenzyl)-l-aspartato] gallium complexes on breast carcinoma and fibrosarcoma cells | Authors | Mohsen, A. ; Collery, P. ; Hassan, R.E. ; Badawi, A. ; Jeannesson, P. ; Desmaële, D. ; Morjani, H. ; Gilane Mohamed Sabry | Issue Date | 2-Aug-2016 | Publisher | SPRINGER | Journal | Journal of Biological Inorganic Chemistry | Volume | 21 | Issue | 7 | Start page | 837 | End page | 849 | DOI | 10.1007/s00775-016-1382-7 | Scopus ID | 2-s2.0-84982836741 | Web of science ID | WOS:000385147900003 |
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