Metformin Addition to Chemotherapy in Stage IV Non-Small Cell Lung Cancer: an Open Label Randomized Controlled Study
Sayed, Rana; Saad, Amr S; El Wakeel, Lamia; Elkholy, Engi; Badary, Osama;
Abstract
Purpose: To evaluate effects of metformin on clinical outcome of non-diabetic patients with stage IV NSCLC. Materials and Methods: A prospective, randomized, open-label, controlled pilot study was conducted on patients with stage IV NSCLC with an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0-2, excluding patients with diabetes and lactic acidosis. Thirty chemo-naïve, non-diabetic patients with stage IV NSCLC were enrolled. Fifteen patients received intravenous gemcitabine/cisplatin regimen alone (arm B) while fifteen patients received the same regimen plus daily oral metformin 500mg (arm A). The effect of metformin on chemotherapy-response rates, survival, and adverse events in these patients was evaluated. Results: Objective response rate (ORR) and median overall survival (OS) in arms A and B were 46.7% versus 13.3% respectively, p=0.109 and 12 months versus 6.5 months, respectively, p=0.119. Median progression free survival (PFS) in arms A and B was 5.5 months versus 5 months, p=0.062. No significant increase in toxicity was observed in arm A versus arm B. Percentage of patients who experienced nausea was significantly lower in arm A versus arm B, at 26.7% versus 66.7% respectively, p=0.028. Conclusions: Metformin administration reduced occurrence of chemotherapy induced-nausea. Non-statistically significant improvements in the ORR or OS were observed. Metformin had no effect on PFS.
Other data
Title | Metformin Addition to Chemotherapy in Stage IV Non-Small Cell Lung Cancer: an Open Label Randomized Controlled Study | Authors | Sayed, Rana ; Saad, Amr S; El Wakeel, Lamia; Elkholy, Engi; Badary, Osama | Affiliations | Department of Clinical Pharmacy - Pharmacy ; Department of Clinical Oncology and Nuclear Medicine - Medicine ; Department of Clinical Pharmacy - Pharmacy ; Department of Clinical Oncology and Nuclear Medicine - Medicine ; Department of Clinical Pharmacy - Pharmacy | Keywords | Lung cancer;Survival;Non-small cell;MTOR;Metformin | Issue Date | Dec-2015 | Journal | Asian Pacific Journal of Cancer Prevention | Volume | 16 | Issue | 15 | Start page | 6621 | End page | 6626 | ISSN | 15137368 | DOI | 10.7314/apjcp.2015.16.15.6621 | PubMed ID | 26434885 | Scopus ID | 2-s2.0-84944454131 |
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