α-Amylase triggered carriers based on cyclodextrin anchored hollow mesoporous silica for enhancing insecticidal activity of avermectin against Plutella xylostella
Amir E. Kaziem; Gao, Yunhao; Zhang, Yuan; Qin, Xueying; Xiao, Yanan; Zhang, Yanhui; You, Hong; Li, Jianhong; He, Shun;
Abstract
α-Amylase-responsive carrier for controlled release of avermectin (AVM) was prepared based on α-cyclodextrin (α-CD) anchored hollow mesoporous silica (HMS) using α-CD as a capping molecule. The release of AVM was studied at different temperatures, pH values and in the presence or absence of α-amylase. The results revealed that the AVM-encapsulated controlled release formulation (AVM-CRF) has a drastic enzymatic dependence, an excellent encapsulation efficacy reaching 38%, and outstanding UV and thermal shielding ability. The AVM-CRF biological activity survey shows excellent toxicological properties against Plutella xylostella larvae, which confirms that α-CD caps could be uncapped enzymatically in vivo and release AVM, inducing P. xylostella larval death. AVM-CRF has a notable capability to keep 0.6 mg L-1 AVM biologically active until 14th day with 83.33% mortality of the target insect, which was 40% higher than that of treated with AVM commercial formulation. The study provides a theoretical basis for the application of pesticide reduction.
Other data
Title | α-Amylase triggered carriers based on cyclodextrin anchored hollow mesoporous silica for enhancing insecticidal activity of avermectin against Plutella xylostella | Authors | Amir E. Kaziem ; Gao, Yunhao; Zhang, Yuan; Qin, Xueying; Xiao, Yanan; Zhang, Yanhui; You, Hong; Li, Jianhong; He, Shun | Keywords | Avermectin;Controlled release formulation;Hollow mesoporous silica;Insecticidal activity;α-Amylase response | Issue Date | 2018 | Publisher | ELSEVIER | Journal | Journal of hazardous materials | ISSN | 0304-3894 | DOI | 10.1016/j.jhazmat.2018.07.059 | PubMed ID | 30036751 | Scopus ID | 2-s2.0-85050151108 | Web of science ID | WOS:000446794400024 |
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