Reactivity of 6-methylchromone-3-carbonitrile towards some nitrogen nucleophilic reagents
Magdy A. Ibrahim; Nasser M. El-Gohary; S.Said;
Abstract
The chemical reactivity of 6-methylchromone-3-carbonitrile (1) was studied towards a variety of nitrogen nucleophiles. A variety of products was obtained from the reaction of carbonitrile 1 with hydrazine hydrate, S-benzyl dithiocarbazate, isonicotinic acid hydrazide and cyanoacetohydrazide. A diversity of Schiff bases bearing 2-amino-6-methylchromone linked variable heterocyclic systems was efficiently synthesized. Reaction of carbonitrile 1 with guanidine and cyanoguanidine resulted in ring conversion producing chromeno[4,3d]pyrimidines. Reaction of carbonitrile 1 was also studied towards some 1,4-binucleophiles.
Other data
Title | Reactivity of 6-methylchromone-3-carbonitrile towards some nitrogen nucleophilic reagents | Authors | Magdy A. Ibrahim ; Nasser M. El-Gohary; S.Said | Issue Date | 2018 | Publisher | Heterocycles | Volume | 96 | Issue | 690 | Start page | 706 |
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