Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6- Methylchromone-3-Carbonitrile
Magdy A. Ibrahim; Nasser M. El-Gohary; Yassin Gabr; S. Said;
Abstract
Abstract: A variety of heteroannulated chromeno[2,3-b]pyridines and their related compounds were efficiently
synthesized from chemical transformations of 6-methylchromone-3-carbonitrile (1) with some cyclic and acyclic carbon
nucleophiles. Also, the reactivity of carbonitrile 1 was studied towards 1-ethyl-4-hydroxy-3-nitroacetylquinolin-2(1H)-one
(8) producing the unexpected 5-ethyl-10-methyl-8H-benzo[h]chromeno[2,3-b][1,6]naphthyridine-6(5H),8-dione (9). A
diversity of 2-substituted-3-cyclohexyl-8-methyl-4H,6H-chromeno[3',2':5,6]pyrido[2,3-d]pyrimidine-4,6-diones were
synthesized. Structures of the newly synthesized products have been deduced on the basis of elemental analysis and
spectral data. The newly prepared compounds were screened for their antimicrobial activity.
synthesized from chemical transformations of 6-methylchromone-3-carbonitrile (1) with some cyclic and acyclic carbon
nucleophiles. Also, the reactivity of carbonitrile 1 was studied towards 1-ethyl-4-hydroxy-3-nitroacetylquinolin-2(1H)-one
(8) producing the unexpected 5-ethyl-10-methyl-8H-benzo[h]chromeno[2,3-b][1,6]naphthyridine-6(5H),8-dione (9). A
diversity of 2-substituted-3-cyclohexyl-8-methyl-4H,6H-chromeno[3',2':5,6]pyrido[2,3-d]pyrimidine-4,6-diones were
synthesized. Structures of the newly synthesized products have been deduced on the basis of elemental analysis and
spectral data. The newly prepared compounds were screened for their antimicrobial activity.
Other data
Title | Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6- Methylchromone-3-Carbonitrile | Authors | Magdy A. Ibrahim ; Nasser M. El-Gohary; Yassin Gabr; S. Said | Issue Date | Sep-2016 | Publisher | Journal of Pharmaceutical and Applied Chemistry | Volume | 2 | Start page | 181 | End page | 187 |
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