Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia
Youssef, Yomna H; Makkeyah, Sara M; Soliman, Ahmed F; Meky, Nefissa H;
Abstract
Asparaginase (ASNase) is a key component in the treatment protocols of childhood acute lymphoblastic leukemia (ALL). Asparagine synthetase (ASNS) and the basic region leucine zipper activating transcription factor 5 (ATF5) mediate the anti-leukemic effect of ASNase. Only a few reports studied the association between polymorphisms in these genes and treatment-related toxicity and response. Therefore, the current study aimed to investigate the association of ASNS and ATF5 polymorphisms with the susceptibility to ASNase-related toxicity and disease outcome in a population of childhood ALL Egyptian patients.
Other data
| Title | Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia | Authors | Youssef, Yomna H; Makkeyah, Sara M; Soliman, Ahmed F ; Meky, Nefissa H | Keywords | Asparagine synthetase (ASNS);Basic region leucine zipper activating transcription factor 5 (ATF5);Childhood acute lymphoblastic leukemia (childhood ALL);Polymorphism;Toxicity | Issue Date | 7-May-2021 | Publisher | Springer | Journal | Cancer Chemotherapy and Pharmacology | Volume | 88 | Start page | 313 | End page | 321 | ISSN | 0344-5704 1432-0843 |
DOI | 10.1007/s00280-021-04290-6 | PubMed ID | 33959786 |
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