Oxidative stress and platelet activation: markers of myocardial infarction in type 2 diabetes mellitus
El-Mesallamy, Hala; Hamdy, Nadia; Suwailem, Salwa; Radwan, Sara;
Abstract
We compared lipids, lipid peroxidation product malondialdehyde (MDA), the acute phase reactant high-sensitivity C-reactive protein (hsCRP), interleukin 1beta (IL-1beta), and platelet selectin (P-selectin) between healthy controls, type 2 diabetes mellitus (DM) participants without myocardial infarction (MI), as well as type 2 DM participants with MI. Malondialdehyde, IL-1beta, and P-selectin levels were significantly higher in the diabetic participants with MI than in either healthy controls or diabetic participants without MI. In the diabetic groups, fasting blood glucose (FBG) level, glycated hemoglobin (HbA(1c)), MDA, hsCRP, and P-selectin were all significantly positively correlated with each other. This study suggests that increased levels of oxidative stress markers, proinflammatory markers, and adhesion molecules contribute to the atherosclerotic process that eventually leads to coronary artery disease in diabetic patients.
Other data
Title | Oxidative stress and platelet activation: markers of myocardial infarction in type 2 diabetes mellitus | Authors | El-Mesallamy, Hala; Hamdy, Nadia; Suwailem, Salwa; Radwan, Sara | Keywords | myocardial infarction;oxidative stress;interleukin 1 beta;P-selectin;diabetes;C-REACTIVE PROTEIN;SOLUBLE P-SELECTIN;INFLAMMATORY MARKERS;TOTAL CHOLESTEROL;ATHEROSCLEROSIS;SERUM;ENDOTHELIN-1;EXPRESSION;ADHESION;DISEASE | Issue Date | 2010 | Publisher | SAGE PUBLICATIONS INC | Journal | International Journal of Angiology | Volume | 61 | Issue | 1 | Start page | 14 | End page | 18 | ISSN | 0003-3197 | DOI | 10.1177/0003319709340891 | PubMed ID | 19759031 | Scopus ID | 2-s2.0-73449138762 | Web of science ID | WOS:000273095600003 |
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