Modulatory effect of rutin on Deca-Durabolin- induced reproductive damage via suppression of oxidative stress and apoptosis in adult male rats.
Aml Salem Saleh Ahmed;
Abstract
Deca- Durabolin (Nandrolone decanoate, ND) treatment causes damage in the male reproductive system. Rutin (RT) is a naturally
occurring flavonoid glycoside that has antioxidant and anti-inflammatory properties. This study aimed to investigate effects of rutin
against ND-induced reproductive toxicity in male rats. Forty adult male rats were used. The control group received olive oil with oral
gavage during 6 weeks. ND Groups received different doses (25, 50, 100 mg Kg-1
, i.m.). RT + ND groups received RT (50 mg kg -1
, P.o.)
during 6 weeks, associated with (25,50,100 mg Kg-1
, i.m.). Biochemical (total protein, testosterone, MDA, SOD and CAT), histological,
histochemical and immunohistochemical studies of testicles were evaluated. ND treatment increased the oxidative stress and
induced testicular degeneration and apoptosis when compared to the control group. However, RT treatment relieves these side
effects when compared to the ND group alone. It is concluded that RT treatment may reduce ND-induced reproductive toxicity as apotential antioxidant compound.
occurring flavonoid glycoside that has antioxidant and anti-inflammatory properties. This study aimed to investigate effects of rutin
against ND-induced reproductive toxicity in male rats. Forty adult male rats were used. The control group received olive oil with oral
gavage during 6 weeks. ND Groups received different doses (25, 50, 100 mg Kg-1
, i.m.). RT + ND groups received RT (50 mg kg -1
, P.o.)
during 6 weeks, associated with (25,50,100 mg Kg-1
, i.m.). Biochemical (total protein, testosterone, MDA, SOD and CAT), histological,
histochemical and immunohistochemical studies of testicles were evaluated. ND treatment increased the oxidative stress and
induced testicular degeneration and apoptosis when compared to the control group. However, RT treatment relieves these side
effects when compared to the ND group alone. It is concluded that RT treatment may reduce ND-induced reproductive toxicity as apotential antioxidant compound.
Other data
Title | Modulatory effect of rutin on Deca-Durabolin- induced reproductive damage via suppression of oxidative stress and apoptosis in adult male rats. | Authors | Aml Salem Saleh Ahmed | Keywords | Nandrolone decanoate;Testes;rutin;apoptosis;oxidative stress | Issue Date | 2017 | Journal | Int. J. Pharm. Sci. Rev. Res. | Volume | 47 | Issue | 2 | Start page | 111 | End page | 118 |
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