Prophylactic effect of vitamin b12 against silicon dioxide nanoparticles- induced hepatotoxicity in adult male rats
Shadia M. Kadry; Amany A. Osman; Aml Salem Saleh Ahmed; Wafaa A. Morsy;
Abstract
Silicon dioxide nanoparticles are increasingly used in various
applications including agriculture, industrial, medical and cosmetics
despite of their toxicity. Vitamin B12 is used as an antioxidant. The aim
of this work is to explore the protective effect of vitamin B12 against
the hepatotoxic potency of silicon nanoparticles in adult male rats.
There was an increase in ALT, AST, ALP and MDA degrees. Also,
there were a decrease in albumin, SOD and GSH levels. Histological,
histochemical and immunochemical studies of hepatic tissue were
evaluated. Silicon nanoparticles treatment increased the oxidative
stress and induced hepatocytes degeneration, apoptosis and disturbance
in polysaccharide, protein and collagen fibers contents when compared
to the control group. However, Vitamin B12 administration relieved these side effects when
compared to the silicon nanoparticles- treated group. It is concluded that vitamin B12 could
reduce silica-induced hepatic toxicity as a potential antioxidant supplement
applications including agriculture, industrial, medical and cosmetics
despite of their toxicity. Vitamin B12 is used as an antioxidant. The aim
of this work is to explore the protective effect of vitamin B12 against
the hepatotoxic potency of silicon nanoparticles in adult male rats.
There was an increase in ALT, AST, ALP and MDA degrees. Also,
there were a decrease in albumin, SOD and GSH levels. Histological,
histochemical and immunochemical studies of hepatic tissue were
evaluated. Silicon nanoparticles treatment increased the oxidative
stress and induced hepatocytes degeneration, apoptosis and disturbance
in polysaccharide, protein and collagen fibers contents when compared
to the control group. However, Vitamin B12 administration relieved these side effects when
compared to the silicon nanoparticles- treated group. It is concluded that vitamin B12 could
reduce silica-induced hepatic toxicity as a potential antioxidant supplement
Other data
Title | Prophylactic effect of vitamin b12 against silicon dioxide nanoparticles- induced hepatotoxicity in adult male rats | Authors | Shadia M. Kadry; Amany A. Osman; Aml Salem Saleh Ahmed ; Wafaa A. Morsy | Keywords | Silicon dioxide nanoparticles;Hepatoxicity;Vitamin B12;Collagen fibersP53 | Issue Date | 2018 | Journal | World Journal of Pharmacy and Pharmaceutical Sciences | Volume | 7 | Issue | 5 | Start page | 38 | End page | 53 | DOI | 10.20959/wjpps20185-11357. |
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