Correlation between Hepatitis B surface antigen titers and HBV DNA levels
Alghamdi, Amal; Aref, Nagwa; El-Hazmi, Malak; Al-Hamoudi, Waleed; Alswat, Khalid; Helmy, Nadia; Sanai, Faisal; Abdo, Ayman;
Abstract
Background/Aim: To assess the correlation between serum HBsAg titers and hepatitis B virus (HBV) DNA levels in patients with hepatitis B envelop antigen-negative (HBeAg -ve) HBV genotype-D (HBV/D) infection. Patients and Methods: A total of 106 treatment- naïve, HBeAg -ve HBV/D patients were included; 78 in the inactive carrier (IC) state and 28 in the active hepatitis (AH) stage. HBV DNA load and HBsAg titers were tested using TaqMan real-time polymerase chain reaction (PCR) and automated chemiluminescent microparticle immunoassay, respectively. Results: The median (range) log10 HBsAg titer was significantly lower in the IC group compared with AH group, 3.09 (-1 to -4.4) versus 3.68 (-0.77 to 5.09) IU/mL, respectively; P < 0.001. The suggested cutoff value of HBsAg titer to differentiate between the two groups was 3.79 log10 IU/mL. In addition, there was a significant positive correlation between HBsAg and HBV DNA levels in the whole cohort, AH, and IC groups (r = 0.6, P < 0.0001; r = 0.591, P = 0.001; and r = 0.243, P = 0.032, respectively). Conclusion: Serum HBsAg titers may correlate with HBV DNA in treatment-naïve HBeAg -ve HBV/D patients, and supports the use of HBsAg levels in clinical practice as a predictor of serum HBV DNA levels.
Other data
Title | Correlation between Hepatitis B surface antigen titers and HBV DNA levels | Authors | Alghamdi, Amal; Aref, Nagwa ; El-Hazmi, Malak; Al-Hamoudi, Waleed; Alswat, Khalid; Helmy, Nadia ; Sanai, Faisal; Abdo, Ayman | Keywords | Genotype D | HBeAg negative | HBV DNA | inactive carrier | quantitative HBsAg | Saudi Arabia | Issue Date | 1-Nov-2013 | Publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | Journal | Saudi Journal of Gastroenterology | Volume | 19 | Issue | 6 | Start page | 252 | End page | 257 | ISSN | 13193767 | DOI | 10.4103/1319-3767.121035 | PubMed ID | 24195978 | Scopus ID | 2-s2.0-84889779667 | Web of science ID | WOS:000327579900003 |
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