MELATONIN PRETREATMENT CAN ENHANCE THE PROTECTIVE ACTION AGAINST ISOPROTERENOL - INDUCED ALTERATION ADVERSELY AFFECTING CARDIAC FUNCTION.
Afaf Abbass Sayed Saleh;
Abstract
Myocardial infarction (MI) is the acute condition of necrosis of the
myocardium that poses a major public health problem in the world.
The purpose of this study was to appraise the possible cardio-protective effects of melatonin against isoproterenol (ISO)- induced MI
in rats. Two days after ISO administration to male Wistar rats (150
mg/kg b.wt/day) exhibits cardiotoxicity that is associated with an
increase in serum levels of C - reactive protein (CRP) and cardiac
troponin - I (cTn - I), as well as excessive production of free radicals
along with profound increase in the serum levels of cardiac injury
markers, creatinine kinase- MB (CK- MB), lactate dehydrogenase
(LDH), aspartate transaminase (AST) and alanine transaminase (ALT),
and a significant decrease in the activities of superoxide dismutase
(SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione - S- transferase(GST)
and the levels of reduced glutathione (GSH), malondialdehyde (MDA), total nitric oxide
(TNO) and myeloperoxidase (MPO). Pretreatment of ISO- injected rats with melatonin at a
dose of 10 mg/kg b. wt. daily for 30 days showed a significant decrease in the levels of lipid
peroxidation and improved the antioxidant status by increasing the activities of antioxidant
enzymes and non - enzymatic antioxidants as well as reduction of inflammatory markers. The
results suggested the potential role of melatonin pretreatment to diminish the ISO - induced
cardiac injury and possess anti - oxidant and free radical scavenger with cardio- protective
properties.
myocardium that poses a major public health problem in the world.
The purpose of this study was to appraise the possible cardio-protective effects of melatonin against isoproterenol (ISO)- induced MI
in rats. Two days after ISO administration to male Wistar rats (150
mg/kg b.wt/day) exhibits cardiotoxicity that is associated with an
increase in serum levels of C - reactive protein (CRP) and cardiac
troponin - I (cTn - I), as well as excessive production of free radicals
along with profound increase in the serum levels of cardiac injury
markers, creatinine kinase- MB (CK- MB), lactate dehydrogenase
(LDH), aspartate transaminase (AST) and alanine transaminase (ALT),
and a significant decrease in the activities of superoxide dismutase
(SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione - S- transferase(GST)
and the levels of reduced glutathione (GSH), malondialdehyde (MDA), total nitric oxide
(TNO) and myeloperoxidase (MPO). Pretreatment of ISO- injected rats with melatonin at a
dose of 10 mg/kg b. wt. daily for 30 days showed a significant decrease in the levels of lipid
peroxidation and improved the antioxidant status by increasing the activities of antioxidant
enzymes and non - enzymatic antioxidants as well as reduction of inflammatory markers. The
results suggested the potential role of melatonin pretreatment to diminish the ISO - induced
cardiac injury and possess anti - oxidant and free radical scavenger with cardio- protective
properties.
Other data
Title | MELATONIN PRETREATMENT CAN ENHANCE THE PROTECTIVE ACTION AGAINST ISOPROTERENOL - INDUCED ALTERATION ADVERSELY AFFECTING CARDIAC FUNCTION. | Authors | Afaf Abbass Sayed Saleh | Keywords | Melatonin; Isoproterenol; Myocardial infarction; hydroxyl radical ; Inflammatory marker | Issue Date | 18-Oct-2018 | Publisher | www.wjpps.com | Journal | WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES | DOI | 10.20959/wjpps201611-7984 |
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