New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
Ebada, Sherif; Müller, Werner E G; Lin, Wenhan; Proksch, Peter;
Abstract
A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC50 values in the low micromolar to nanomolar range.
Other data
| Title | New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens | Authors | Ebada, Sherif ; Müller, Werner E G; Lin, Wenhan; Proksch, Peter | Keywords | Jaspis splendens; cytotoxic activity; jasplakinolide Z5; jasplakinolide Z6 | Issue Date | 6-Feb-2019 | Publisher | MDPI | Journal | Marine drugs | ISSN | 1660-3397 | DOI | 10.3390/md17020100 | PubMed ID | 30736370 | Scopus ID | 2-s2.0-85061225541 | Web of science ID | WOS:000460795500028 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.