New secondary metabolites from the mangrove-derived fungus Aspergillus sp. AV-2
Elissawy, AM; Ebada, Sherif; El-Neketi, M; Ebrahim, W; Singab, AB; Ashour, M.L.;
Abstract
Chemical investigation of the mangrove-derived fungus Aspergillus sp. AV-2 following fermentation on solid rice medium led to the isolation of a new phenyl pyridazine derivative (1) and a new prenylated benzaldehyde derivative, dioxoauroglaucin (2), together with fourteen known compounds (3-16). Chemical structures of the new compounds were unambiguously determined based on HRESIMS and extensive 1D and 2D NMR spectroscopic analyses. Compounds 2-7, 8 and 13 were assessed for their antiproliferative activity against Caco-2 cell lines, where flavoglaucin (6) revealed the most potent cytotoxicity with IC50 of 2.87 μM.
Other data
Title | New secondary metabolites from the mangrove-derived fungus Aspergillus sp. AV-2 | Authors | Elissawy, AM; Ebada, Sherif ; El-Neketi, M; Ebrahim, W; Singab, AB; Ashour, M.L. | Keywords | Aspergillus sp.; Mangrove; Endophyte; Prenylated benzaldehyde; Pyridazine; Antiproliferative activity; NATURAL-PRODUCTS; DERIVATIVES; VERSICOLOR; DESIGN | Issue Date | 2019 | Publisher | ELSEVIER SCIENCE BV | Journal | PHYTOCHEMISTRY LETTERS | ISSN | 1874-3900 | DOI | 10.1016/j.phytol.2018.10.014 | Scopus ID | 2-s2.0-85056198297 | Web of science ID | WOS:000456346200001 |
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