Spiroarthrinols a and B, two novel meroterpenoids isolated from the spongederived fungus Arthrinium sp
Elissawy, AM; Ebada, Sherif; Ozkaya, FC; Ebrahim, W; Singab, AB; Ashour, M.L.; Proksch P.;
Abstract
Chemical investigation of the sponge derived fungus Arthrinium sp. following fermentation on solid rice medium led to the isolation of two new meroterpenoidal alcohols spiroarthrinols A (1) and B (2) together with eighteen known compounds (3-20). The structures and relative configuration of the new compounds were unambiguously determined based on HRESIMS and extensive 1D and 2D NMR spectroscopic analyses. In addition, a plausible biosynthetic pathway for the new compounds spiroarthrinols A (1) and B (2) was postulated encompassing a mixed polyketide/terpenoid pathway. When assessed for their antiproliferative activity against Caco-2 cell lines, none of the isolated compounds showed significant cytotoxicity.
Other data
Title | Spiroarthrinols a and B, two novel meroterpenoids isolated from the spongederived fungus Arthrinium sp | Authors | Elissawy, AM; Ebada, Sherif ; Ozkaya, FC; Ebrahim, W; Singab, AB; Ashour, M.L.; Proksch P. | Keywords | Marine derived fungi; Arthrinium; Spiro compounds; Cytotoxicity; POLYCYCLIC SPIRO LIGNANS; ENDOPHYTIC FUNGUS; BIOACTIVE METABOLITES; MARINE; CONSTITUENTS; GRISEOFULVIN; DERIVATIVES; APOPTOSIS; CANCER; ACID | Issue Date | 2017 | Publisher | ELSEVIER | Journal | PHYTOCHEMISTRY LETTERS | ISSN | 1874-3900 | DOI | 10.1016/j.phytol.2017.05.008 | Scopus ID | 2-s2.0-85019254934 | Web of science ID | WOS:000405467600049 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.