Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa
Ebada, Sherif; Linh, Mai Hoang; Longeon, Arlette; de Voogd, Nicole J; Durieu, Emilie; Meijer, Laurent; Bourguet-Kondracki, Marie-Lise; Müller, Werner E G; Proksch, Peter; Singab A.;
Abstract
Chemical investigation of methanolic extracts of the two Indonesian marine sponges Stylissa massa and Stylissa flabelliformis yielded 25 bromopyrrole alkaloids including 2 new metabolites. The structures of all isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR, LR-MS and HR-MS analyses. All isolated compounds were assayed for their antiproliferative and protein kinase inhibitory activities. Several of the tested compounds revealed selective activity(ies) which suggested preliminary SARs of the isolated bromopyrrole alkaloids.
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Title | Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa | Authors | Ebada, Sherif ; Linh, Mai Hoang; Longeon, Arlette; de Voogd, Nicole J; Durieu, Emilie; Meijer, Laurent; Bourguet-Kondracki, Marie-Lise; Müller, Werner E G; Proksch, Peter; Singab A. | Keywords | antiproliferative; bromopyrrole alkaloids; neurodegenerative disorders; protein kinase | Issue Date | Feb-2015 | Publisher | TAYLOR & FRANCIS LTD | Journal | Natural product research | ISSN | 1478-6419 | DOI | 10.1080/14786419.2014.947496 | PubMed ID | 25116895 | Scopus ID | 2-s2.0-84919836152 | Web of science ID | WOS:000346586100005 |
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