Psychrophilin E, a new cyclotripeptide, from co-fermentation of two marine alga-derived fungi of the genus Aspergillus
Ebada, Sherif; Fischer, Thomas; Hamacher, Alexandra; Du, Feng-Yu; Roth, Yoen Ok; Kassack, Matthias U; Wang, Bin-Gui; Roth, Eckhard H;
Abstract
Chemical investigation of the mycelial extract of a mixed culture of two marine alga-derived fungal strains of the genus Aspergillus has yielded one new cyclotripeptide, psychrophilin E (1), the recently reported oxepin-containing alkaloids, protuboxepin A (2) and oxepinamide E (3), together with three other polyketide derivatives (4-6). The chemical structure and relative and absolute configurations of psychrophilin E (1) were unambiguously established based on HRMS, 1D, 2D NMR and chiral-phase HPLC analysis of its hydrolysate. All the isolated compounds were assessed for their anti-proliferative activity against four different human cancer cell lines and some of them revealed selective activities.
Other data
Title | Psychrophilin E, a new cyclotripeptide, from co-fermentation of two marine alga-derived fungi of the genus Aspergillus | Authors | Ebada, Sherif ; Fischer, Thomas; Hamacher, Alexandra; Du, Feng-Yu; Roth, Yoen Ok; Kassack, Matthias U; Wang, Bin-Gui; Roth, Eckhard H | Keywords | Aspergillus; anti-proliferative; co-fermentation; marine-derived fungi | Issue Date | 2014 | Journal | Natural product research | ISSN | 14786419 | DOI | 10.1080/14786419.2014.880911 | PubMed ID | 24483240 | Scopus ID | 2-s2.0-84901021776 |
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