Efficacy of tumor necrosis factor and interleukin-10 analysis in the follow-up of nonalcoholic fatty liver disease progression
Zahran, Walid E.; Salah El-Dien, Kholoud A.; Kamel, Philip G.; El-Sawaby, Ahmed Shawky;
Abstract
Tumor necrosis factor (TNF-α) is a cytokine involved in systemic inflammation during acute phase reactions. The current study was designed to investigate the levels of pro-inflammatory cytokine (TNF-α) along with the anti-inflammatory cytokine (IL-10) during progression of non-alcoholic fatty liver disease (NAFLD) from simple steatosis to non-alcoholic steatohepatitis (NASH) and fibrosis in diabetic patients, and correlate the levels of cytokines with the progression of NAFLD. Fifty-two diabetic patients compared to 18 healthy controls were participated in this study. Based on clinical diagnosis, patients were divided into three groups: simple steatosis, NASH and fibrosis. Serum liver function tests, fasting blood glucose, bilirubin, ALT, AST, TNF-α, IL-10 and lipid profile were measured. TNF-α levels were significantly higher in NAFLD patients compared to control subjects with a significant positive correlation with body mass index and fasting blood glucose (FBG) but with negative correlation with IL-10. Serum IL-10 levels were significantly lower in NAFLD patients compared with controls. A positive correlation between IL-10 and HDL-C with concomitant negative correlation between IL-10 and FBG and triacylglycerides was found. Cytokine analyses showed that there was a prominent imbalance between TNF-α and IL-10 in patients with NAFLD, and this imbalance increase by increasing the progression of NAFLD especially in obese diabetic patients. TNF-α and IL-10 could be used in diagnosis and follow-up of NAFLD stages in a way to avoid liver biopsies in greater proportion of patients. © 2012 Association of Clinical Biochemists of India.
Other data
Title | Efficacy of tumor necrosis factor and interleukin-10 analysis in the follow-up of nonalcoholic fatty liver disease progression | Authors | Zahran, Walid E. ; Salah El-Dien, Kholoud A.; Kamel, Philip G.; El-Sawaby, Ahmed Shawky | Keywords | Diagnosis | Interleukin-10 | Non-alcoholic fatty liver disease | Progression | Steatohepatitis | Tumor necrosis factor-alpha | Issue Date | 1-Apr-2013 | Journal | Indian Journal of Clinical Biochemistry | ISSN | 09701915 | DOI | 10.1007/s12291-012-0236-5 | PubMed ID | 24426199 | Scopus ID | 2-s2.0-84891832887 |
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