Ameliorative effect of glabridin, a main component of Glycyrrhiza glabra L. roots in streptozotocin induced Type 1 diabetes in male albino rats
Abd-El-Ghffar, Eman A.;
Abstract
Glabridin (component of Licorice), a major flavonoid of Glycyrrhiza glabra L. (Fabaceae), is commonly used in the treatment of cardiovascular and central nervous system diseases. Also, it has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, estrogenic and anti-osteoporotic. Here, we investigated the antidiabetic effects of oral treatment with glabridin on streptozotocin (STZ)-induced diabetic rats. Type 1 diabetes was induced in male albino rats by a single intraperitoneal injection of STZ (60 mg/kg body weight). Diabetes appeared after 1-3 days after STZ injection. The animals were randomly divided into6 groups (7 animals each) as follows; Group 1: Normal control group (negative control group); Group 2 & 3: glabridin-treated control groups (25&50 mg/kg body weight); Group 4:STZ diabetic group (positive control group); Group 5 & 6:glabridin treated diabetic groups(25&50 mg/kg body weight). In normal rats, no harmful effects were detected after orally administration of both doses of glabridin on all parameters measured.The antidiabetic activity of glabridin (especially high dose) was mediated through significantly increased the body weight gain, enzymic/non-enzymic antioxidants and HDL-cholesterol, and significantly decreased relative organ weights, serum glucose, lipid profiles, lipid peroxidation (LPO), pro-inflammatory cytokine, liver and kidney functions. The present study indicated that the anti-inflammatory/anti-oxidant activity of glabridin (especially high dose) may have beneficial effects against complications shown in STZ diabetic rats.
Other data
Title | Ameliorative effect of glabridin, a main component of Glycyrrhiza glabra L. roots in streptozotocin induced Type 1 diabetes in male albino rats | Authors | Abd-El-Ghffar, Eman A. | Keywords | Blood glucose | Cytokine | Diabetic rats | Kidney function | Licorice | Lipid profile | Liver enzymes | Issue Date | 1-Oct-2016 | Journal | Indian Journal of Traditional Knowledge | ISSN | 09725938 | Scopus ID | 2-s2.0-84990195416 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.