Influence of vitamin C or/and L-methionine on hyperglycaemia, hyperlipidaemia and hematological alterations in alloxan-induced diabetes in rats
Abd-El-Ghffar, Eman A.; Barakat, Alaa; Shehata, Safa Mohamed;
Abstract
Background: Here, we assessed the possible therapeutic potential of vitamin C or/and L-methionine on some biochemical and hematological alterations in alloxan-induced diabetes in rats. Diabetes was induced by single intraperitoneal (100 mg/kg b.w, i.p) dose of alloxan monohydrate solution. The animals were randomly grouped into five as follows: the normal control group, diabetic control group, diabetic treated with vitamin C (Vit C) group, diabetic treated with L-methionine (L-Meth) group, diabetic treated with Vit C and L-Meth group. The regimens were given once daily for four weeks. Significant disturbances in glucose, glycated hemoglobin, lipid profiles, prothrombin time (PT), partial thromboplastin time (PTT), some hematological and oxidant/antioxidant parameters was observed in diabetic control rats. Only the combination of Vit C and L-Meth had the most beneficial effect on hyperglycemia, dyslipidemia, abnormal coagulation indices and oxidative stress in alloxan-induced diabetes in rats. From the present data, we concluded that Vit C and L-Meth in combination may have therapeutic effects against the risks of the metabolic syndrome and coronary artery diseases and could improve the health of rats with diabetes mellitus.
Other data
Title | Influence of vitamin C or/and L-methionine on hyperglycaemia, hyperlipidaemia and hematological alterations in alloxan-induced diabetes in rats | Authors | Abd-El-Ghffar, Eman A. ; Barakat, Alaa; Shehata, Safa Mohamed | Keywords | Antioxidant | L-methionine | Oxidative stress | Partial thromboplastin time | Prothrombin time | Vitamin C | Issue Date | 1-Jan-2018 | Publisher | MATTIOLI 1885 | Journal | Progress in Nutrition | ISSN | 11298723 | DOI | 10.23751/pn.v20i2-S.5418 | Scopus ID | 2-s2.0-85062564942 | Web of science ID | WOS:000467821100032 |
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