Synthesis, Antibacterial, and Antiviral Evaluation of New Heterocycles Containing Pyridine Moiety
Salem, Marwa S.; Sakr, Sameh I.; El-Senousy, Waled M.; Hassan M. F. Madkour;
Abstract
A facile one-pot four-component reaction was utilized to construct 2-oxo-1,2-dihydropyridine-3-carbonitrile as a scaffold for the synthesis of many fused heterocyclic systems, namely, furopyridine, pyridothiadiazepinthione, and pyridotriazine, as well as non-fused heterocyclic systems such as phthalazin-2(1H)-ylnicotinonitrile, pyridin-2-yl-1H-pyrazole, and pyrazol-1-ylnicotino-nitrile,1-(3-cyanopyridin-2-yl)-1H-pyrazole. The new compounds were evaluated as antimicrobial and antiviral agents. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Other data
| Title | Synthesis, Antibacterial, and Antiviral Evaluation of New Heterocycles Containing Pyridine Moiety | Authors | Salem, Marwa S. ; Sakr, Sameh I.; El-Senousy, Waled M.; Hassan M. F. Madkour | Keywords | 2-Pyridone;Antimicrobial activity;Antivirus activity;Furo[2,3-b]pyridine;Nicotinonitrile | Issue Date | 1-Oct-2013 | Journal | Archiv der Pharmazie | Volume | 346 | Issue | 10 | Start page | 766 | End page | 773 | ISSN | 03656233 | DOI | 10.1002/ardp.201300183 | PubMed ID | 24105721 | Scopus ID | 2-s2.0-84885677623 |
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