Penile length and genital anomalies in Egyptian male newborns: epidemiology and influence of endocrine disruptors
mohamed, elkholy; Hamza, Rasha Tarif; Saleh, Mohamed; Elsedfy, Heba;
Abstract
This is an attempt to establish the normal stretched penile length and prevalence of male genital anomalies in full-term neonates and whether they are influenced by prenatal parental exposure to endocrine-disrupting chemicals. A thousand newborns were included; their mothers were subjected to the following questionnaire: parents' age, residence, occupation, contact with insecticides and pesticides, antenatal exposure to cigarette smoke or drugs, family history of genital anomalies, phytoestrogens intake and history of in vitro fertilization or infertility. Free testosterone was measured in 150 neonates in the first day of life. Mean penile length was 3.4±0.37 cm. A penile length <2.5 cm was considered micropenis. Prevalence of genital anomalies was 1.8% (hypospadias 83.33%). There was a higher rate of anomalies in those exposed to endocrine disruptors (EDs; 7.4%) than in the non-exposed (1.2%; p<0.0001; odds ratio 6, 95% confidence interval 2-16). Mean penile length showed a linear relationship with free testosterone and was lower in neonates exposed to EDs.
Other data
Title | Penile length and genital anomalies in Egyptian male newborns: epidemiology and influence of endocrine disruptors | Authors | mohamed, elkholy ; Hamza, Rasha Tarif; Saleh, Mohamed; Elsedfy, Heba | Keywords | endocrine disruptors; genital anomalies; male; penile length; testosterone; TESTICULAR DYSGENESIS SYNDROME; CONGENITAL-MALFORMATIONS; EXTERNAL GENITALIA; HYPOSPADIAS; TRENDS; MICROPENIS; CRYPTORCHIDISM; PREVALENCE; DISORDERS; CHEMICALS | Issue Date | 2013 | Publisher | WALTER DE GRUYTER GMBH | Journal | Journal of pediatric endocrinology & metabolism : JPEM | ISSN | 0334-018X | DOI | 10.1515/jpem-2012-0350 | PubMed ID | 23509209 | Scopus ID | 2-s2.0-84879051614 | Web of science ID | WOS:000318500400015 |
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