Regioselective Green Synthesis and Antimicrobial properties of full fused non mixed Heterocyclic Systems
Maher A. El-Hashash; Sameh A. Rizk; El-Hag, Amira;
Abstract
Presently, green chemistry is a pro-active approach to pollution prevention. Additionally, enhancing the efficiency of
organic synthesis, lowering the consumption of chemicals. Green Chemistry is designing chemical products and
processes that reduce time, chemical, solvents, reduced hazards and obtaining heterocyclic compounds from simple
starting materials which are fundamental goals in organic synthesis1-5. Grinding considered as simplest green chemistry
protocol which has proven to be an efficient, economical and environmentally benign process. 1,2,4-Triazines play an
essential task in various biological routes and in synthesis of drugs. Therefore, a lot of heterocyclic systems attitude 1,2,4-
triazines are found to have significant pharmacological effects6-13. That targets have anti-AIDS14,15, antiviral16, anticancer17-
20, antimicrobial21-24, antitumor25, antithelmintic drugs26. The nature of substituent in 1,2,4-triazines have prompt affect on
the orientation of cyclization reaction27, so that the substituted at position 6 of 3-hydrazino-5-hydroxy-1,2,4-triazine effect
on the orientation of cyclization to form 1,2,4-triazolo[1,2,4]triazines. When the substituent was an electron with drawing
group, 1,2,4-triazolo[3,4-c][1,2,4]triazines were created in neutral or acidic medium, while, when substituted was an
electron donating group and the reagent was acidic 1,2,4-triazolo[4,3-b][1,2,4]triazines were produced.
organic synthesis, lowering the consumption of chemicals. Green Chemistry is designing chemical products and
processes that reduce time, chemical, solvents, reduced hazards and obtaining heterocyclic compounds from simple
starting materials which are fundamental goals in organic synthesis1-5. Grinding considered as simplest green chemistry
protocol which has proven to be an efficient, economical and environmentally benign process. 1,2,4-Triazines play an
essential task in various biological routes and in synthesis of drugs. Therefore, a lot of heterocyclic systems attitude 1,2,4-
triazines are found to have significant pharmacological effects6-13. That targets have anti-AIDS14,15, antiviral16, anticancer17-
20, antimicrobial21-24, antitumor25, antithelmintic drugs26. The nature of substituent in 1,2,4-triazines have prompt affect on
the orientation of cyclization reaction27, so that the substituted at position 6 of 3-hydrazino-5-hydroxy-1,2,4-triazine effect
on the orientation of cyclization to form 1,2,4-triazolo[1,2,4]triazines. When the substituent was an electron with drawing
group, 1,2,4-triazolo[3,4-c][1,2,4]triazines were created in neutral or acidic medium, while, when substituted was an
electron donating group and the reagent was acidic 1,2,4-triazolo[4,3-b][1,2,4]triazines were produced.
Other data
Title | Regioselective Green Synthesis and Antimicrobial properties of full fused non mixed Heterocyclic Systems | Authors | Maher A. El-Hashash; Sameh A. Rizk; El-Hag, Amira | Issue Date | 20-Jun-2017 | Publisher | cirworld | Journal | Journal of Advances in Chemistry | Volume | 13 | Issue | 12 | Start page | 6130 | End page | 6144 | DOI | https://doi.org/10.24297/jac.v13i12.6188 |
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