Synthesis of bioactive 4-oxo-4H-chromenes bearing heterocyclic systems from hydrazonecarbodithioic acid and thiocarbohydrazone
Ali, TE; Abdel-Aziz, SA; Metwally El-Shaaer, Hafez; Hanafy, FI; El-Fauomy, AZ;
Abstract
Condensation 4-oxo-4H-chromene-3-carboxaldehydes (1a,b) with acid hydrazine-carbodithioic acid and/or thiocarbohydrazide afforded hydrazonecarbodithioic acid 2, monothiocarbohydrazone 3a,b and bisthiocarbohydrazone 4, respectively. Heterocyclization of 2-4 via reaction with oxygen, sulfur and/or halogen reagents in different media yielded pyridazinethione 5; 1,3-thiazoles 7; pyrazoles 9-12; 1,2,4-thiadiazoles 8,13,14, and 23; 1,2,4-triazolethiones 15-17; 1,2,4-triazinethiones 18-22; imidazolethione 24 and pyrimidinethione 25 derivatives. Antifungal activity was screened for some the new synthesized compounds. Formulations of all products have been deduced by elemental analysis and spectral data (IR, 1H NMR and Mass spectroscopy). Copyright © Taylor & Francis Group, LLC.
Other data
Title | Synthesis of bioactive 4-oxo-4H-chromenes bearing heterocyclic systems from hydrazonecarbodithioic acid and thiocarbohydrazone | Authors | Ali, TE; Abdel-Aziz, SA; Metwally El-Shaaer, Hafez ; Hanafy, FI; El-Fauomy, AZ | Keywords | antifungal activity;hydrazonecarbodithioic acid;DERIVATIVES;PRODUCTS;thiocarbohydrazone;synthesis;heterocycles;chromone | Issue Date | 2008 | Publisher | TAYLOR & FRANCIS LTD | Journal | Phosphorus, Sulfur and Silicon and the Related Elements | ISSN | 1042-6507 | DOI | 10.1080/10426500701851291 | Scopus ID | 2-s2.0-49549106035 | Web of science ID | WOS:000258384400006 |
Attached Files
File | Description | Size | Format | Existing users please Login |
---|---|---|---|---|
Phosphorus.pdf | 566.92 kB | Adobe PDF | Request a copy |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.