Comparative effect of vitamin D3 and carbenoxolone treatments in metabolic syndrome rats
Saleh, Nermine; Seif, Ansam Aly; Bahaa, Ienass; Abdel-Hady, Enas A.;
Abstract
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including central obesity, hypertension, insulin resistance, dyslipidemia, and hyperglyemia. MetS is found to be a positive predictor of cardiovascular morbidity and mortality. The present study was planned to test the efficacy of vitamin D3 supplementation as compared with cortisol inhibition on MetS parameters. Wistar rats were allocated into four groups: control, untreated MetS, and MetS treated with either vitamin D3 (10 µg/kg) or carbenoxolone (50 mg/kg). MetS was induced by combination of high-fat diet and oral fructose. After the induction period (8 weeks), MetS was confirmed, and treatment modalities started for a further 4 weeks. Compared with untreated MetS, vitamin D3- and carbenoxolone-treated rats showed significant reduction in blood pressure, body mass index, Lee index, waist circumference, retroperitoneal fat, and improvement of dyslipidemia. Meanwhile, treatment with carbenoxolone significantly lowered the elevated liver enzymes, and vitamin D3 resulted in improved insulin sensitivity, enhanced glucose uptake by muscles, and replenished glycogen content in the liver and muscles near control levels. In conclusion, although treatment with vitamin D3 or carbenoxolone reduced the risk factors associated with MetS, vitamin D3 was effective in ameliorating insulin resistance which is the hallmark of MetS.
Other data
Title | Comparative effect of vitamin D3 and carbenoxolone treatments in metabolic syndrome rats | Authors | Saleh, Nermine; Seif, Ansam Aly; Bahaa, Ienass; Abdel-Hady, Enas A. | Keywords | vitamine D3;carbenoxolone;carbénoxolone;cortisol;dyslipidemia;dyslipidémie;insulin resistance;metabolic syndrome;obesity;obésité;résistance à l’insuline;syndrome métabolique;vitamin D3 | Issue Date | 2-Dec-2021 | Journal | Canadian Journal of physiology and pharmacology | ISSN | 0008-4212 1205-7541 |
DOI | 10.1139/cjpp-2021-0400 | PubMed ID | 34855519 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.