Astaxanthin Ameliorates Doxorubicin-Induced Cognitive Impairment (Chemobrain) in Experimental Rat Model: Impact on Oxidative, Inflammatory, and Apoptotic Machineries
El-Agamy, Sara Emad; Abdel-Aziz, Amal Kamal; Sara Abdel Moneim Wahdan; Esmat, Ahmed; Azab, Samar S;
Abstract
Chemobrain refers to a common sequelae experienced by 15-80% of cancer patients exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been implicated in a strenuous neurotoxicity manifested as decline in cognitive functions, most probably via cytokine-induced oxidative and nitrosative damage to brain tissues. Astaxanthin (AST), a naturally occurring carotenoid, is reputable for its outstanding antioxidant, anti-inflammatory, and antiapoptotic activities. Therefore, the aim of the current study was to investigate the potential neuroprotective and memory-enhancing effects of AST against DOX-induced behavioral and neurobiological abnormalities. Briefly, AST treatment (25 mg/kg) significantly protected against DOX-induced memory impairment. Furthermore, AST restored hippocampal histopathological architecture, halted DOX-induced oxidative and inflammatory insults, mitigated the increase in acetylcholinesterase activity, and consistently downregulated the overactive apoptotic machineries. In conclusion, these findings suggest that AST offers neuroprotection against DOX-induced cognitive impairment which could be explained at least partly by its antioxidant, anti-inflammatory, and antiapoptotic effects.
Other data
Title | Astaxanthin Ameliorates Doxorubicin-Induced Cognitive Impairment (Chemobrain) in Experimental Rat Model: Impact on Oxidative, Inflammatory, and Apoptotic Machineries | Authors | El-Agamy, Sara Emad; Abdel-Aziz, Amal Kamal; Sara Abdel Moneim Wahdan ; Esmat, Ahmed; Azab, Samar S | Keywords | Apoptosis;Astaxanthin;Chemobrain;Doxorubicin;Neuroinflammation;Oxidative stress | Issue Date | Jul-2018 | Publisher | SPRINGER | Journal | Molecular neurobiology | Volume | 55 | Start page | 5727 | End page | 5740 | ISSN | 0893-7648 | DOI | 10.1007/s12035-017-0797-7 | PubMed ID | 29039023 | Scopus ID | 2-s2.0-85031913175 | Web of science ID | WOS:000434805100024 |
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