Synthesis of novel pyrazole derivatives as Antineoplastic Agent
El-Hag, Amira; Sameh A. Rezk;
Abstract
Anticancer evaluation of pyrazole 2 and Schiff base 5 is reported. Synthesis of some important heterocyclic
compounds via 2,3-diaryloxirane-2,3-dicarbonitrile 1, pyrazole 2, and Schiff base 5 with different
nitrogen nucleophiles afforded new routes for synthesized fused heterocyclic derivatives. These compounds
can be used as a key starting materials to synthesize some important imidazolo-[4,5-c]pyrazole,
pyrazolo[3,4-e]1,2,4-triaging, imidazolo[3,2-b]pyrazole, and pyrazolo-pyrazine, as anticancer reagents
showed good results at optimum conditions (400–500 ppm), particularly the bridge head nitrogen compounds,
and could be used to improve them. Electromeric effect of the halogen atom in the aryl moieties
can be controlled upon the rate of reaction and the yield of the product. The structure of the synthesized
new compounds would be characterized by elemental and spectral data.
compounds via 2,3-diaryloxirane-2,3-dicarbonitrile 1, pyrazole 2, and Schiff base 5 with different
nitrogen nucleophiles afforded new routes for synthesized fused heterocyclic derivatives. These compounds
can be used as a key starting materials to synthesize some important imidazolo-[4,5-c]pyrazole,
pyrazolo[3,4-e]1,2,4-triaging, imidazolo[3,2-b]pyrazole, and pyrazolo-pyrazine, as anticancer reagents
showed good results at optimum conditions (400–500 ppm), particularly the bridge head nitrogen compounds,
and could be used to improve them. Electromeric effect of the halogen atom in the aryl moieties
can be controlled upon the rate of reaction and the yield of the product. The structure of the synthesized
new compounds would be characterized by elemental and spectral data.
Other data
Title | Synthesis of novel pyrazole derivatives as Antineoplastic Agent | Authors | El-Hag, Amira ; Sameh A. Rezk | Issue Date | 16-Apr-2017 | Publisher | Wily | Journal | JOURNAL OF HETEROCYCLIC CHEMISTRY | DOI | DOI 10.1002/jhet.2956 |
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