Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis
Abdel-Maged, Amany El-Shahawy; Gad, Amany M; Abdel-Aziz, Amal Kamal; Azab, Samar S; Aboulwafa, Mohammad M;
Abstract
Although the precise etiology of Rheumatoid arthritis (RA) remains obscure, heightened immune response is thought to play a vital role in provoking joint inflammation and bone erosion. This study aims at comparatively evaluating the effects of two monoclonal antibodies Ranibizumab (RANI) as anti-VEGF antibody and Tocilizumab (TCZ) as interleukin-6 receptor (IL-6R) antagonist, against adjuvant induced arthritis in rats. CFA-induced arthritic rats were treated for three consecutive weeks with Methotrexate (MTX), TCZ and RANI monotherapy. Clinical assessment of RA, bone erosion, inflammatory, angiogenic and apoptotic markers were determined to assess the anti-arthritic effect. Liver enzymes and histopathological examination of liver and spleen were assessed to evaluate the toxicity profile of the tested therapeutic agents. MTX, TCZ and RANI monotherapy significantly enhanced the anti-arthritic parameters in comparison with the Complete Freund's Adjuvant (CFA)-induced arthritic rats through significant reduction of ankle and paw swelling. Also, they significantly reduced inflammatory, angiogenic and apoptotic markers. Importantly, Ranibizumab showed better effect than the standard anti-rheumatic drugs Methotrexate (MTX) or Tocilizumab (TCZ) in bone protection and cartilage health; hence proves to be a promising new therapeutic agent for RA.
Other data
Title | Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis | Authors | Abdel-Maged, Amany El-Shahawy; Gad, Amany M; Abdel-Aziz, Amal Kamal ; Azab, Samar S; Aboulwafa, Mohammad M | Keywords | Adjuvant induced arthritis;Tocilizumab;Ranibizumab;Immune Response | Issue Date | 2018 | Publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | Journal | Toxicology and applied pharmacology | ISSN | 0041008X | DOI | 10.1016/j.taap.2018.07.014 | PubMed ID | 30025850 | Scopus ID | 2-s2.0-85050924340 | Web of science ID | WOS:000444662600008 |
Attached Files
File | Description | Size | Format | Existing users please Login |
---|---|---|---|---|
1-s2.0-S0041008X18303272-main.pdf | 4.25 MB | Adobe PDF | Request a copy |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.