Anti-inflammatory activity of flavonoids from Chrozophora tinctoria
Abdallah, Hossam M.; Almowallad, Fahad M.; Ahmed Esmat; Shehata, Ibrahim A.; Abdel-Sattar, Essam A.;
Abstract
Abstract Chemical investigation of Chrozophora tinctoria (L.) A. Juss. growing in Saudi Arabia revealed the isolation of two new acylated flavonoids identified as acacetin-7-O-β-d-[α-l-rhamnosyl(1 → 6)]3″-E-p-coumaroyl glucopyranoside (4) and apigenin-7-O-(6″-Z-p-coumaroyl)-β-d-glucopyranoside (5), in addition to amentoflavone (1), apigenin-7-O-β-d-glucopyranoside (2), apigenin-7-O-6″-E-p-coumaroyl-β-d-glucopyranoside (3) and rutin (6). The structures of isolated compounds were established by 1D, 2D NMR and HRESIMS spectral data, in addition to comparison with literature data. The anti-inflammatory activities of isolated compounds were assessed by measuring the levels of IL-1β, IL-6, TNF-α and PGE2 in the supernatant media of human peripheral blood mononuclear cells (PBMCs) stimulated by phytohaemagglutinin (PHA). At a concentration of 100 μM, compounds 1, 2, 4 and 6 significantly decreased Il-1β, Il-6 and PGE2 to nearly normal values. All tested compounds caused a dose-dependent decrease in TNF-α level but failed to reach that of the control values.
Other data
Title | Anti-inflammatory activity of flavonoids from Chrozophora tinctoria | Authors | Abdallah, Hossam M.; Almowallad, Fahad M.; Ahmed Esmat ; Shehata, Ibrahim A.; Abdel-Sattar, Essam A. | Keywords | Acylated apigenin;Acylated flavonoids;Euphorbiaceae;Interleukin;Prostaglandin E;TNF-α | Issue Date | 3-Jun-2015 | Publisher | ELSEVIER | Journal | Phytochemistry Letters | ISSN | 18743900 | DOI | 10.1016/j.phytol.2015.05.008 | Scopus ID | 2-s2.0-84930637498 | Web of science ID | WOS:000362174600013 |
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