Efficacy of Albendazole Mass Treatment Alone Compared to Combined Albendazole – Flubendazole Regimen for Treatment of Resistant Enterobius vermicularis Infection in Children
Elkholy, Amal;
Abstract
Background: Enterobius vermicularis is one of the most common parasitic helminths causing infection in children
worldwide causing distressing lifestyle and health problems. The empirical use of anthelminthic drugs without medical
supervision and low compliance to treatment protocols lead to resistance to therapy.
Objective: To assess the efficacy of albendazole mass treatment alone compared to the combined albendazoleflubendazole regimen for treatment of recurrent and resistant Enterobius vermicularis infection in children and their
families.
Subject and Methods: It was a clinical trial that included 130 children 3-12 years old with resistant Enterobius
vermicularis infection determined by the following inclusion criteria for treatment resistance. This study was carried
out at the Pediatrics outpatient Clinic at Al-Azhar University Hospitals, and the Medical Parasitology Department at
Damietta Faculty of Medicine, Al-Azhar University at New Damietta city, Egypt.
Results: 36 out of 65 (55.4%) children in the albendazole treated group and 54 out of 65(83.1%) in the albendazoleflubendazole treated group was cured with significantly higher efficacy for the albendazole-flubendazole regimen. The
laboratory data showed improvement in post-treatment phase especially for albendazole- flubendazole treated groups
for hemoglobin%, total leukocytic counts, neutrophil and lymphocyte counts that improved by time and a decline in the
reported eosinophilia. The clinical data were significantly warning the presence of infection however they did not define
the significance of treatment efficacy or resistance.
Conclusion: Enterobiasis is a childhood health problem with potential resistance to regular therapeutic protocols. Using
albendazole- flubendazole combined regimen showed promising results in the treated groups superior to albendazole
alone against resistant Enterobius vermicularis infection in children. This gives promising results encouraging further
evaluation studies.
worldwide causing distressing lifestyle and health problems. The empirical use of anthelminthic drugs without medical
supervision and low compliance to treatment protocols lead to resistance to therapy.
Objective: To assess the efficacy of albendazole mass treatment alone compared to the combined albendazoleflubendazole regimen for treatment of recurrent and resistant Enterobius vermicularis infection in children and their
families.
Subject and Methods: It was a clinical trial that included 130 children 3-12 years old with resistant Enterobius
vermicularis infection determined by the following inclusion criteria for treatment resistance. This study was carried
out at the Pediatrics outpatient Clinic at Al-Azhar University Hospitals, and the Medical Parasitology Department at
Damietta Faculty of Medicine, Al-Azhar University at New Damietta city, Egypt.
Results: 36 out of 65 (55.4%) children in the albendazole treated group and 54 out of 65(83.1%) in the albendazoleflubendazole treated group was cured with significantly higher efficacy for the albendazole-flubendazole regimen. The
laboratory data showed improvement in post-treatment phase especially for albendazole- flubendazole treated groups
for hemoglobin%, total leukocytic counts, neutrophil and lymphocyte counts that improved by time and a decline in the
reported eosinophilia. The clinical data were significantly warning the presence of infection however they did not define
the significance of treatment efficacy or resistance.
Conclusion: Enterobiasis is a childhood health problem with potential resistance to regular therapeutic protocols. Using
albendazole- flubendazole combined regimen showed promising results in the treated groups superior to albendazole
alone against resistant Enterobius vermicularis infection in children. This gives promising results encouraging further
evaluation studies.
Other data
Title | Efficacy of Albendazole Mass Treatment Alone Compared to Combined Albendazole – Flubendazole Regimen for Treatment of Resistant Enterobius vermicularis Infection in Children | Authors | Elkholy, Amal | Keywords | Pinworm;Enterobius vermicularis;Flubendazole;Albendazole;Resistance | Issue Date | Jul-2021 | Journal | Egyptian Journal of Hospital Medicine | Volume | 84 | Start page | 2071 | End page | 2077 |
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