Chrysin attenuates testosterone-induced benign prostate hyperplasia in rats
Shoieb, Sherif M.; Ahmed Esmat; Khalifa, Amani E.; Abdel-Naim, Ashraf B.;
Abstract
Benign prostate hyperplasia (BPH) is a common age-related health problem affecting almost 3 out of 4 men in their sixties. Chrysin is a dietary phytoestrogen found naturally in bee propolis and various plant extracts. It possesses antioxidant, anti-inflammatory and anti-proliferative properties. The current study was conducted to explore the role chrysin plays in protection against testosterone-induced BPH in rats. On grounds of a preliminary experiment, a dose of chrysin (50 mg/kg) was chosen for further investigation. Testosterone significantly depleted glutathione, suppressed superoxide dismutase and catalase activities, and elevated lipid peroxidation. Moreover, it markedly scaled down the level of cleaved caspase-3 enzyme, reduced Bax/Bcl-2 ratio and mRNA expression of p53 and p21; conversely, protein expression of proliferating cell nuclear antigen was enhanced. Chrysin alleviated testosterone-induced oxidative stress and restored cleaved caspase-3 level, Bax/Bcl-2 ratio and mRNA expression of p53 and p21 to almost control levels. Chrysin prevented the increase in binding activity of nuclear factor kappa B (NF-κB) p65 subunit, mRNA expression of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor 1 receptor (IGF-1R). These data highlight the protective role of chrysin against experimentally-induced BPH. This is attributed - at least partly - to its antioxidant, antiproliferative and proapoptotic properties.
Other data
Title | Chrysin attenuates testosterone-induced benign prostate hyperplasia in rats | Authors | Shoieb, Sherif M.; Ahmed Esmat ; Khalifa, Amani E.; Abdel-Naim, Ashraf B. | Keywords | BPH | Chrysin | Prostate | Rats | Testosterone | Issue Date | 1-Jan-2018 | Publisher | PERGAMON-ELSEVIER SCIENCE LTD | Journal | Food and Chemical Toxicology | Volume | 111 | Start page | 650 | End page | 659 | ISSN | 02786915 | DOI | 10.1016/j.fct.2017.12.017 | PubMed ID | 29247772 | Scopus ID | 2-s2.0-85038120363 | Web of science ID | WOS:000423248100059 |
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