Passive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats
Ibrahim, Shaimaa; Osman, Rihab; Mortada, Nahed D.; Geneidy, Ahmed Shawky; Awad, Gehanne A.S.;
Abstract
Pulmonary bed can retain microparticles (MP) larger than their capillaries’ diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP for IV use. Lung tolerability and targeting efficiency of Enox-Alb MS were tested, and the pharmacokinetic profile following IV administration to albino rats was constructed. In vivo studies confirmed high lung targeting efficiency of Enox-Alb MS with lack of potential tissue toxicity. The anticoagulant activity of the selected Alb MS was significantly sustained for up to 38 h compared to 5 h for the market product. Alb MS are promising delivery carriers for controlled and targeted delivery of Enox to the lungs for prophylaxis and treatment of pulmonary embolism.
Other data
Title | Passive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats | Authors | Ibrahim, Shaimaa ; Osman, Rihab; Mortada, Nahed D.; Geneidy, Ahmed Shawky; Awad, Gehanne A.S. | Keywords | Albumin;Anticoagulant;Controlled delivery;Enoxaparin;Microspheres;Passive lung targeting | Issue Date | 3-Feb-2017 | Publisher | TAYLOR & FRANCIS LTD | Journal | Drug Delivery | Volume | 24 | Issue | 1 | Start page | 243 | End page | 251 | ISSN | 10717544 | DOI | 10.1080/10717544.2016.1245368 | PubMed ID | 28156170 | Scopus ID | 2-s2.0-85014812478 | Web of science ID | WOS:000395077800024 |
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