Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity
El Newahie, Aliya M S; Ismail, Nasser S M; Abou El Ella, Dalal; Abouzid, Khaled;
Abstract
Quinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic compounds. Quinoxalines have drawn great attention due to their wide spectrum of biological activities. They are considered as an important basis for anticancer drugs due to their potential activity as protein kinase inhibitors. In this review, we focus on the chemistry of the quinoxaline derivatives, the strategies for their synthesis, their potential activities against various tyrosine kinases, and on the structure-activity relationship studies reported to date.
Other data
Title | Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity | Authors | El Newahie, Aliya M S; Ismail, Nasser S M; Abou El Ella, Dalal ; Abouzid, Khaled | Keywords | Anticancer;Kinase inhibitors;Quinoxalines;SAR;Synthetic strategies | Issue Date | May-2016 | Publisher | WILEY-V C H VERLAG GMBH | Journal | Archiv der Pharmazie | Volume | 349 | Issue | 5 | Start page | 309 | End page | 326 | ISSN | 0365-6233 | DOI | 10.1002/ardp.201500468 | PubMed ID | 27062086 | Scopus ID | 2-s2.0-84963815326 | Web of science ID | WOS:000375726600001 |
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