DESIGN, SYNTHESIS AND BLOOD PRESSURE LOWERING ACTIVITY OF CERTAIN TETRAHYDROBENZO [b] THIOPHENE DERIVATIVES WITH ARYLPIPERAZINYL SIDE CHAINS
Khaled A M Abouzid; Azza Taher; Mona M. Kamel;
Abstract
Blocking the action of adrenergic neurotransmitters on α1-adrenoreceptor is a well known approach for the clinical treatment of hypertension. Thus, novel compounds characterized by tetrahydrobenzo[b]thiophene or their annelated tetrahydrobenzo[b]thieno[2,3-d]pyrimidin-4(3H)ones connected through an alkyl spacer to arylpiperazine residue were designed and synthesized as structural analogues to prazosin as α1-adrenoreceptor (α1-AR) antagonists. The synthesized compounds were screened for their effect on blood pressure of normotensive cats. Some of these compounds displayed appreciable hypotensive activity compared to prazosin as reference standard.
Other data
Title | DESIGN, SYNTHESIS AND BLOOD PRESSURE LOWERING ACTIVITY OF CERTAIN TETRAHYDROBENZO [b] THIOPHENE DERIVATIVES WITH ARYLPIPERAZINYL SIDE CHAINS | Authors | Khaled A M Abouzid ; Azza Taher; Mona M. Kamel | Keywords | hypertension;thienopyrimidine;thiophene;arylpiperazine and alfa -blockers | Issue Date | 16-Jul-2007 | Journal | Bull. Fac. Pharm. Cairo Univ. | Volume | 45 | Issue | 2 | Start page | 75 | End page | 85 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.