Biochemical studies of hippocampal gene expression of brain-derived neurotropic factor and toll-like receptor-4 in diabetic rats exposed to chronic stress: Effects of antidepressant drugs
Aboul-Fotouh, Sawsan; Hassan, Doaa Mohamed; Habib, Mohamed Z.; Amin, Ahmed Ibrahim; Kassim, Samar Kamal; Mohamed, Amr Saad;
Abstract
Objective: Depression and diabetes are closely associated in a reciprocal manner, leading to significant morbidity and mortality with an evidence of a pro-inflammatory state underlying pathophysiology of both diseases. Unfortunately, little information is available about the effects of antidepressant drugs on hippocampal brain-derived neurotrophic factor (BDNF) and toll-like receptor-4 (TLR-4) expression in diabetes. Methods: We investigated the effect of chronic administration of fluoxetine (FLU) and imipramine (IMIP) on behavioral, metabolic, and inflammatory abnormalities in diabetic and non-diabetic rats exposed to chronic restraint stress (CRS). Results: Both diabetes and CRS induced depressive-like behavior which was more prominent in diabetic/depressed rats; this was reversed by chronic treatment with FLU and IMIP. Diabetic and non-diabetic rats exposed to CRS showed a significant increase in hippocampal expression of TLR-4 and pro-inflammatory cytokines alongside a decrease in BDNF expression. FLU and IMIP ameliorated these inflammatory abnormalities. Conclusion: Diabetes mellitus (DM) and chronic stress induced a depressive-like behavior associated with an increase in hippocampal expression of TLR-4, tumor necrosis factor-α, and interleukin-1ß with a significant correlation to decreased BDNF expression. FLU and IMIP showed comparable effects regards the improvement of depressive and inflammatory abnormalities associated with DM.
Other data
Title | Biochemical studies of hippocampal gene expression of brain-derived neurotropic factor and toll-like receptor-4 in diabetic rats exposed to chronic stress: Effects of antidepressant drugs | Authors | Aboul-Fotouh, Sawsan ; Hassan, Doaa Mohamed; Habib, Mohamed Z. ; Amin, Ahmed Ibrahim; Kassim, Samar Kamal; Mohamed, Amr Saad | Keywords | Brain-derived neurotrophic factor;Chronic restraint stress;Depression;Diabetes mellitus;Fluoxetine;Imipramine;Toll-like receptor-4 | Issue Date | 1-Jan-2018 | Journal | Asian Journal of Pharmaceutical and Clinical Research | Volume | 11 | Issue | 1 | ISSN | 09742441 | DOI | 10.22159/ajpcr.2018.v11i1.21593 | Scopus ID | 2-s2.0-85039872640 |
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