Propranolol restores susceptibility of XDR Gram-negative pathogens to meropenem and Meropenem combination has been evaluated with either tigecycline or amikacin
Mabrouk, Samar S; Abdellatif, Ghada R; Zaid, Ahmed S Abu; Aboshanab K. M.;
Abstract
Infection with extensive-drug-resistant (XDR) carbapenem-resistant (CR) Gram-negative bacteria (GNB) are viewed as a serious threat to human health because of the limited therapeutic options. This imposes the urgent need to find agents that could be used as adjuvants or combined with carbapenems to enhance or restore the susceptibility of XDR CR- GNB. Therefore, this study aimed to examine the effect of propranolol (PR) in combination with Meropenem (MEM) on the susceptibility profile of XDR CR-GNB recovered from severely infected patients as well as to evaluate combining MEM with either tigecycline (TGC) or amikacin (AK).
Other data
| Title | Propranolol restores susceptibility of XDR Gram-negative pathogens to meropenem and Meropenem combination has been evaluated with either tigecycline or amikacin | Authors | Mabrouk, Samar S; Abdellatif, Ghada R; Zaid, Ahmed S Abu; Aboshanab K. M. | Keywords | Carbapenem-resistant; Extensive-drug-resistant; Meropenem; Or amikacin; Propranolol; Tigecycline | Issue Date | 22-Jul-2023 | Journal | BMC microbiology | ISSN | 1471-2180 | DOI | 10.1186/s12866-023-02934-6 | PubMed ID | 37481513 |
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