Metformin Reduces the Risk of Diabetic Neuropathy Among Egyptian Type 2 Diabetic Patients: A Case-Control Study
Yomne Hicham; Mona Abdelsalam Besibes; Amr A Mahfouz; Lamia El Wakeel; Sayed, Rana;
Abstract
This study aimed to investigate the association of different patient factors with the occurrence of diabetic peripheral neuropathy (DPN) among type 2 diabetes mellitus patients. A case-control study was conducted on a total sample of 180 Egyptian type 2 diabetic patients. A full medical, medication, social, and family history was collected for the recruited sample. Glycated hemoglobin, lipid profile, and microalbuminuria were assessed. Among 180 patients recruited, 128 patients suffered from DPN. Low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were higher among patients suffering from DPN (p-value = 0.007 and 0.005, respectively). Metformin usage was the only factor that showed a significant decrease in the odds of developing DPN (odds ratio 0.511, 95% confidence interval 0.264- 0.911). Subgroup analysis showed that metformin decreased DPN among males rather than females (p-value = 0.006 vs 0.616, respectively). In conclusion, Serum LDL-C and TC are both determinants for increased risk of DPN among type 2 diabetic patients. Metformin usage decreases DPN in a sex-specific dimorphic fashion where females are less liable to the protective effect of metformin against DPN.
Other data
Title | Metformin Reduces the Risk of Diabetic Neuropathy Among Egyptian Type 2 Diabetic Patients: A Case-Control Study | Other Titles | Associating Factors of Diabetic Neuropathy in Egyptians | Authors | Yomne Hicham; Mona Abdelsalam Besibes; Amr A Mahfouz; Lamia El Wakeel; Sayed, Rana | Keywords | Diabetes Mellitus;Diabetic Neuropathy;Metformin;Egyptian Population;Sex-Specific Response | Issue Date | 1-Dec-2023 | Journal | Archives of Pharmaceutical Science Ain Shams University | Volume | 7 | Issue | 2 | Start page | 432 | End page | 439 | DOI | 10.21608/APS.2023.250911.1145 |
Attached Files
File | Description | Size | Format | Existing users please Login |
---|---|---|---|---|
APS_Volume 7_Issue 2_Pages 432-439 1.pdf | 350.28 kB | Adobe PDF | Request a copy |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.