Toxicological Study of Gbberellic Acid on Liver , Kidney And Brain And Its Apostasy In Adult Abino Rats

Abstract

The aim of this study investigate the toxicity effect of (GA3) on liver & kideny function, activity of acetylcholine and antioxidant at different doses as well as the possibility of recovery after apostasy GA3 Twenty five adult male albino Rats were .equally divided into five groups. Group 1 served as control. Groups 2&3 received GA3 daily in drinking water in two gradually increasing doses of 100 and 200 ppm, respectively for 8 weeks. Groups 4 &5 received the same treatment of GA3 as the second and third groups then were left without any treatment for another 8 weeks Groups (2& 3) were receivedGA3 in both doses ,showed ahighly significant increase in Alanine aminotransferase (ALT),Aspatate aminotransferase (AST), Alkaline phosphatase (ALP) and Gamma-Glutamyl transferase(GGT) Also, elevation of serum in urea ,creatinine ,uric acid and α fetoprotein increase in MDA but decrease in antioxidant enzyme(glutathione GSH & Superoxide dismutase SOD) and decrease in activity of acetylcholine but the result showed improvement after recovery for another eight weeks specific the dose of 100ppm. the previously mentioned results we can conclude that GA3 inhas adose depedent toxic effect on liver kidney and Acetylcholine activity also, oxidative stress following of another eight weeks without drinking GA3in water the result showed Ameliorative in resuts.