Effects of combined diethylcarbamazine and albendazole treatment of bancroftian filariasis on parasite uptake and development in Culex pipiens L
Farid, H.A.; Hammad, Ragaa; Abd El-Bar, Marah Mohammad Hassan Abd El-Bar; Ramzy, R.M.R.; El Setouhy, M.; Weil, G.J.;
Abstract
We studied effects of combined diethylcarbamazine (DEC) and albendazole (ALB) treatment on
Wuchereria bancrofti microfilaria (MF) uptake and development of infective larvae (L3) in Culex pipiens. Consenting
Egyptian adults with microfilaremia (MF > 300/mL) were treated with one or seven daily doses of DEC/ALB. Laboratory-
reared mosquitoes were fed on subjects before and after treatment. MF uptake and infectivity (assessed by
mosquito dissection) were reduced by 89.6% and 82.9%, respectively, 12 months after single-dose treatment and by
96.2% and 99.7%, respectively, after multi-dose treatment. The L3:mosquito ratio decreased by 88% to 0.082 after
single-dose treatment and by 99.8% to 0.001 after multi-dose treatment. If high coverage rates can be achieved for
several annual cycles, mass drug administration (MDA) with DEC/ALB has the potential to decrease transmission to
unsustainable levels and eliminate filariasis in populations. Multi-dose MDA (especially in the first year) might interrupt
transmission with fewer cycles than single-dose treatment.
Wuchereria bancrofti microfilaria (MF) uptake and development of infective larvae (L3) in Culex pipiens. Consenting
Egyptian adults with microfilaremia (MF > 300/mL) were treated with one or seven daily doses of DEC/ALB. Laboratory-
reared mosquitoes were fed on subjects before and after treatment. MF uptake and infectivity (assessed by
mosquito dissection) were reduced by 89.6% and 82.9%, respectively, 12 months after single-dose treatment and by
96.2% and 99.7%, respectively, after multi-dose treatment. The L3:mosquito ratio decreased by 88% to 0.082 after
single-dose treatment and by 99.8% to 0.001 after multi-dose treatment. If high coverage rates can be achieved for
several annual cycles, mass drug administration (MDA) with DEC/ALB has the potential to decrease transmission to
unsustainable levels and eliminate filariasis in populations. Multi-dose MDA (especially in the first year) might interrupt
transmission with fewer cycles than single-dose treatment.
Other data
Title | Effects of combined diethylcarbamazine and albendazole treatment of bancroftian filariasis on parasite uptake and development in Culex pipiens L | Authors | Farid, H.A. ; Hammad, Ragaa ; Abd El-Bar, Marah Mohammad Hassan Abd El-Bar ; Ramzy, R.M.R. ; El Setouhy, M. ; Weil, G.J. | Issue Date | 2005 | Journal | American Journal of Tropical Medicine and Hygiene | Series/Report no. | 73(1),;pp. 108–114 | DOI | http://www.scopus.com/inward/record.url?eid=2-s2.0-24644484110&partnerID=MN8TOARS http://www.scopus.com/inward/record.url?eid=2-s2.0-24644484110&partnerID=MN8TOARS |
Scopus ID | 2-s2.0-24644484110 |
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