The neuroprotective action of naringenin on oseltamivir (Tamiflu) treated male rats
ali, elham; Sabry, Hend; Hoda G. Hegazy;
Abstract
The aim of this study is to evaluate the protective action of naringenin (a flavonoid) on
the brain functions of oseltamivir treated rats. 24 rats were divided into 4 groups as follows: control,
naringenin treated rats (Nar, 50 mg/kg bwt/day), oseltamivir treated rats (Tam, 0.75 mg/kg bwt
twice daily) and naringenin + oseltamivir treated rats (Nar+ Tam). All the drugs were received
via oral gavage for five days. The animals on the 5th day were trained in Y maze. Then, on the
6th day, rats were decapitated and the brain was excised for determination of total antioxidant
capacity (TAC), total oxidant capacity (TOC), total nitric oxide (TNO), Ca ATPase, total cytochrome
P450 (CYP450) contents and brain fatty acid binding proteins FABP7. The results showed
a significant increase in the TOC, TNO and CYP450 in Tam treated rats while a significant decrease
was noticed in TAC, Ca ATPase and FABP7 in the same group in comparison with the control.
Nar +Tam treated rats exhibited a significant decrease in TOC, TNO and CYP450 and a significant
increase in TAC, Ca ATPase and FABP7 in comparison with Tam treated rats. An improvement
in Y maze behavior and all the investigated parameters was noticed in Nar+ Tam treated
rats as compared with the oseltamivir treated rats. The results suggest that Nar has a neurophysiological
and behavioral protective effect on oseltamivir side effects on the brain functions
the brain functions of oseltamivir treated rats. 24 rats were divided into 4 groups as follows: control,
naringenin treated rats (Nar, 50 mg/kg bwt/day), oseltamivir treated rats (Tam, 0.75 mg/kg bwt
twice daily) and naringenin + oseltamivir treated rats (Nar+ Tam). All the drugs were received
via oral gavage for five days. The animals on the 5th day were trained in Y maze. Then, on the
6th day, rats were decapitated and the brain was excised for determination of total antioxidant
capacity (TAC), total oxidant capacity (TOC), total nitric oxide (TNO), Ca ATPase, total cytochrome
P450 (CYP450) contents and brain fatty acid binding proteins FABP7. The results showed
a significant increase in the TOC, TNO and CYP450 in Tam treated rats while a significant decrease
was noticed in TAC, Ca ATPase and FABP7 in the same group in comparison with the control.
Nar +Tam treated rats exhibited a significant decrease in TOC, TNO and CYP450 and a significant
increase in TAC, Ca ATPase and FABP7 in comparison with Tam treated rats. An improvement
in Y maze behavior and all the investigated parameters was noticed in Nar+ Tam treated
rats as compared with the oseltamivir treated rats. The results suggest that Nar has a neurophysiological
and behavioral protective effect on oseltamivir side effects on the brain functions
Other data
Title | The neuroprotective action of naringenin on oseltamivir (Tamiflu) treated male rats | Authors | ali, elham ; Sabry, Hend ; Hoda G. Hegazy | Keywords | Y maze; Brain; TNO; Ca ATPase; CYP450; FABP7 | Issue Date | Dec-2016 | Publisher | The Journal of Basic & Applied Zoology | Source | The Journal of Basic & Applied Zoology | Journal | Journal of basic and applied zoology | Series/Report no. | 77; | ISSN | 2090-9896 |
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