Hematological studies on black cumin oil from the seeds of Nigella sativa L
Enomoto S.; Asano R.; Iwahori Y.; Narui T.; Okada Y.; Singab A.; Okuyama T.;
Abstract
The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation and blood coagulation. By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol (1) and two known compounds, thymol (2), carvacrol (3), having very strong inhibitory activity. Further, we then examined the isolated compounds (1-3) and eight related compounds by the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis.
Other data
Title | Hematological studies on black cumin oil from the seeds of Nigella sativa L | Authors | Enomoto S. ; Asano R. ; Iwahori Y. ; Narui T. ; Okada Y. ; Singab A. ; Okuyama T. | Issue Date | 5-Apr-2001 | Journal | Biological and Pharmaceutical Bulletin | DOI | 3 http://api.elsevier.com/content/abstract/scopus_id/0035080283 307 24 10.1248/bpb.24.307 |
PubMed ID | 24 | Scopus ID | 2-s2.0-0035080283 |
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